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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1946 1
1953 1
1963 2
1971 1
1973 1
1974 1
1975 5
1976 9
1977 6
1978 10
1979 10
1980 18
1981 8
1982 18
1983 19
1984 17
1985 26
1986 22
1987 13
1988 20
1989 9
1990 9
1991 12
1992 15
1993 19
1994 13
1995 18
1996 10
1997 12
1998 24
1999 18
2000 14
2001 23
2002 17
2003 24
2004 19
2005 18
2006 21
2007 17
2008 23
2009 26
2010 37
2011 39
2012 39
2013 29
2014 29
2015 36
2016 35
2017 30
2018 35
2019 32
2020 41
2021 46
2022 50
2023 45
2024 15

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1,022 results

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Page 1
CSF, blood-brain barrier, and brain drug delivery.
Pardridge WM. Pardridge WM. Expert Opin Drug Deliv. 2016 Jul;13(7):963-75. doi: 10.1517/17425247.2016.1171315. Epub 2016 Apr 11. Expert Opin Drug Deliv. 2016. PMID: 27020469 Review.
INTRODUCTION: There are 2 misconceptions about the cerebrospinal fluid (CSF), the blood-brain barrier (BBB), and brain drug delivery, which date back to the discovery of a barrier between blood and brain over 100 years ago. ...AREAS COVERED: Drug distribution into t …
INTRODUCTION: There are 2 misconceptions about the cerebrospinal fluid (CSF), the blood-brain barrier (BBB), and brain drug delivery, …
Structure and function of the blood-brain barrier.
Abbott NJ, Patabendige AA, Dolman DE, Yusof SR, Begley DJ. Abbott NJ, et al. Neurobiol Dis. 2010 Jan;37(1):13-25. doi: 10.1016/j.nbd.2009.07.030. Epub 2009 Aug 5. Neurobiol Dis. 2010. PMID: 19664713 Review.
Neural signalling within the central nervous system (CNS) requires a highly controlled microenvironment. Cells at three key interfaces form barriers between the blood and the CNS: the blood-brain barrier (BBB), blood-CSF barrier and the arachnoi …
Neural signalling within the central nervous system (CNS) requires a highly controlled microenvironment. Cells at three key interfaces form …
SARS-CoV-2 Infects the Brain Choroid Plexus and Disrupts the Blood-CSF Barrier in Human Brain Organoids.
Pellegrini L, Albecka A, Mallery DL, Kellner MJ, Paul D, Carter AP, James LC, Lancaster MA. Pellegrini L, et al. Cell Stem Cell. 2020 Dec 3;27(6):951-961.e5. doi: 10.1016/j.stem.2020.10.001. Epub 2020 Oct 13. Cell Stem Cell. 2020. PMID: 33113348 Free PMC article.
We find that infected cells are apolipoprotein- and ACE2-expressing cells of the choroid plexus epithelial barrier. Finally, we show that infection with SARS-CoV-2 damages the choroid plexus epithelium, leading to leakage across this important barrier that normally …
We find that infected cells are apolipoprotein- and ACE2-expressing cells of the choroid plexus epithelial barrier. Finally, we show …
Gut microbiota regulates blood-cerebrospinal fluid barrier function and Abeta pathology.
Xie J, Bruggeman A, De Nolf C, Vandendriessche C, Van Imschoot G, Van Wonterghem E, Vereecke L, Vandenbroucke RE. Xie J, et al. EMBO J. 2023 Sep 4;42(17):e111515. doi: 10.15252/embj.2022111515. Epub 2023 Jul 10. EMBO J. 2023. PMID: 37427561 Free PMC article.
Administration of SCFAs in App(NL-G-F) mice improved the subcellular localization of TJs at the blood-CSF barrier, reduced the beta-amyloid (Abeta) burden, and affected microglial phenotype. Altogether, our results suggest that modulating the microbiota and a …
Administration of SCFAs in App(NL-G-F) mice improved the subcellular localization of TJs at the blood-CSF barrier, redu …
Development of the choroid plexus and blood-CSF barrier.
Liddelow SA. Liddelow SA. Front Neurosci. 2015 Mar 3;9:32. doi: 10.3389/fnins.2015.00032. eCollection 2015. Front Neurosci. 2015. PMID: 25784848 Free PMC article. Review.
By far, the most widely recognized choroid plexus role is as the site of the blood-CSF barrier, controller of the internal CNS microenvironment. Mechanisms involved combine structural diffusion restraint from tight junctions between plexus epithelial cells (p …
By far, the most widely recognized choroid plexus role is as the site of the blood-CSF barrier, controller of the inter …
Blood-CSF-barrier permeability in tuberculous meningitis and its association with clinical, MRI and inflammatory cytokines.
Shukla R, Kalita J, Haldar R, Misra UK. Shukla R, et al. J Neuroimmunol. 2022 Nov 15;372:577954. doi: 10.1016/j.jneuroim.2022.577954. Epub 2022 Aug 28. J Neuroimmunol. 2022. PMID: 36075158
Blood -cerebrospinal fluid-barrier (BCB) disruption in tuberculous meningitis (TBM) may be mediated by inflammatory cytokines, and may determine clinico-radiological severity and outcome. ...
Blood -cerebrospinal fluid-barrier (BCB) disruption in tuberculous meningitis (TBM) may be mediated by inflammatory cytokines, and ma …
Streptococcus pneumoniae meningitis and the CNS barriers.
Gil E, Wall E, Noursadeghi M, Brown JS. Gil E, et al. Front Cell Infect Microbiol. 2023 Jan 4;12:1106596. doi: 10.3389/fcimb.2022.1106596. eCollection 2022. Front Cell Infect Microbiol. 2023. PMID: 36683708 Free PMC article. Review.
All require SPN to bind to and translocate across the vascular endothelial barrier, and subsequently the basement membrane and perivascular structures, including an additional epithelial barrier in the case of the blood-CSF barrier. ...The inter …
All require SPN to bind to and translocate across the vascular endothelial barrier, and subsequently the basement membrane and periva …
Evaluation of Blood-CSF Barrier Transport by Quantitative Real Time Fluorescence Microscopy.
Sun A, Wang J. Sun A, et al. Pharm Res. 2022 Jul;39(7):1469-1480. doi: 10.1007/s11095-022-03251-9. Epub 2022 Apr 11. Pharm Res. 2022. PMID: 35411508
PURPOSE: Transporters at the blood-cerebrospinal fluid (CSF) barrier (BCSFB) play active roles in removing drugs and toxins from the CSF. ...
PURPOSE: Transporters at the blood-cerebrospinal fluid (CSF) barrier (BCSFB) play active roles in removing drugs and toxins from the …
Chemokine CXCL13 in serum, CSF and blood-CSF barrier function: evidence of compartment restriction.
Pilz G, Sakic I, Wipfler P, Kraus J, Haschke-Becher E, Hitzl W, Trinka E, Harrer A. Pilz G, et al. Fluids Barriers CNS. 2020 Feb 24;17(1):7. doi: 10.1186/s12987-020-0170-5. Fluids Barriers CNS. 2020. PMID: 32089130 Free PMC article.
Elevation levels, however, vary a lot and "leaking" of CXCL13 from blood across dysfunctional brain barriers is a possible source. The aim was to clarify the relation between CXCL13 concentrations in CSF, CXCL13 concentrations in serum and blood-CSF barrie …
Elevation levels, however, vary a lot and "leaking" of CXCL13 from blood across dysfunctional brain barriers is a possible source. Th …
Global alterations to the choroid plexus blood-CSF barrier in amyotrophic lateral sclerosis.
Saul J, Hutchins E, Reiman R, Saul M, Ostrow LW, Harris BT, Van Keuren-Jensen K, Bowser R, Bakkar N. Saul J, et al. Acta Neuropathol Commun. 2020 Jun 26;8(1):92. doi: 10.1186/s40478-020-00968-9. Acta Neuropathol Commun. 2020. PMID: 32586411 Free PMC article.
The choroid plexus (CP) is a highly vascularized structure located in the ventricles that forms the blood-CSF barrier (BCSFB) and separates the blood from the cerebrospinal fluid (CSF). In addition to its role as a physical barrier, the CP functions in …
The choroid plexus (CP) is a highly vascularized structure located in the ventricles that forms the blood-CSF barrier ( …
1,022 results